产品详情
|
Catalog No. |
P1303 |
|
Name |
3’,4’-Didehydro-3’-deoxycytidine |
|
Synonyms |
3’-Deoxy-3’,4’-didehydro-cytidine; DDHC |
|
中文名称 |
|
|
Formula |
C9H11N3O4 |
|
FW |
225.20 |
|
CAS No. |
386264-46-6 |
|
Purity |
≥ 97% |
|
Property |
white or off-white solid Solubility: slightly soluble in DMSO and water Storage: sealed container at room temperature |
|
Package |
Packed as desired |
|
Classification |
Nucleoside Derivatives; Biologically Important Derivatives |
|
Application & Biological Property |
This cytidine analogue has the ability to prevent the replication of several viruses, including the Zika virus. It is also naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin. It is a metabolite of 3’-deoxy-3’,4’-didehydro-CTP. It has a role as an antiviral agent, a human blood serum metabolite, a protein synthesis inhibitor and an RdRp polymerase inhibitor. |
|
References |
1, Mehta, R.; Chekmeneva, E.; Jackson, H.; Sands, C. et. al. Med. 2022, 3, 204-215; 2, Lee, J. H.; Wood, J. M.; Almo, S. C.; Evans, G. B.; Harris, L. D. Grove, T. L. ACS Bio & Med. Chem. 2023, 3, 322-326. 3, Ebrahimi, K. H.; Howie, D.; Rowbotham, J. S.; McCullagh, J.; Armstrong, F. A.; James, W. S. FEBS Lett. 2020, 594, 1624-1630. |
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攀纳燊（河南）医药科学技术有限公司
地址：河南自贸试验区郑州片区（经开）航海路经开第二大街航海东路1291号
邮箱：haifeng.zhang@pannacean.com
电话号码:0371-55159968