2’-甲氧基鸟苷
目录号：
所属分类：
核苷衍生物
应用与生物特性：
产品详情
|
Catalog No. |
P1153 |
|
Name |
2’-O-Methylguanosine |
|
Synonyms |
|
|
中文名称 |
2’-甲氧基鸟苷 |
|
Formula |
C11H15N5O5 |
|
FW |
297.27 |
|
CAS No. |
2140-71-8 |
|
Purity |
≥ 98% |
|
Property |
Appearance and Property: white or off-white solid m. p.: 227–231 ℃ Solubility: slightly soluble in DMSO and water Storage: sealed at 2–8 °C or at room temperature |
|
Package |
Packed as desired |
|
Classification |
Nucleoside Derivatives |
|
Application & Biological Property |
Naturally-occurring RNA modified nucleoside Gm for vaccine and cancer research. It is a component of many nucleic acids and is usually found as a minor component in RNA. It is produced in tRNAs by the action of tRNA guanosine-2’-O-methyl transferase, using S-adenosyl-L-methionine as a substrate. This modification increases the stability of RNAs and antisense drugs. It has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme’s active site. |
|
References |
1. Persson, B. C., Jäger, G.; Gustafsson, C. Nucleic Acids Res. 1997, 25, 4093-4097. 2. Yamagami, R.; Tomikawa, C.; Shigi, N.; et al. Genes Cells 2016, 21, 740-754. |
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攀纳燊（河南）医药科学技术有限公司
地址：河南自贸试验区郑州片区（经开）航海路经开第二大街航海东路1291号
邮箱：haifeng.zhang@pannacean.com
电话号码:0371-55159968