5-氯-2’-脱氧尿嘧啶核苷
目录号：
所属分类：
核苷衍生物
应用与生物特性：
产品详情
|
Catalog No. |
P1118 |
|
Name |
5-Chloro-2’-deoxyuridine |
|
Synonyms |
|
|
中文名称 |
5-氯-2’-脱氧尿嘧啶核苷 |
|
Formula |
C9H11ClN2O5 |
|
FW |
262.65 |
|
CAS No. |
50-90-8 |
|
Purity |
≥ 98% |
|
Property |
Appearance and Property: white or off-white solid; m. p.: 176–179 °C (lit.) Solubility: soluble in DMSO, slightly soluble in methanol and water Storage: sealed at 2–8 °C or room temperature Acute Toxicity: LD50 (IP, rats): > 2000 mg/kg |
|
Package |
Packed as desired |
|
Classification |
Nucleoside Derivatives 核苷衍生物 |
|
Application & Biological Property |
Anticancer agent; Radio-sensitizing agent for cancer treatment; 可用于研究次氯酸对DNA和DNA前体的破坏作用。When 5-Chloro-2’-deoxy uridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-chloro-2’-deoxyuridine in the media does not alter cell division kinetics. It is metabolized and incorporated into DNA using antibodies that binds electively to DNA containing halogenated bases. It is more similar to BrdU in acting as a T analog. The toxicity of 5-chloro-2’-deoxy uridine could in part be attributed to inhibition of thymidylate synthase. |
在线留言
*注：请务必信息填写准确，并保持通讯畅通，我们会尽快与你取得联系
攀纳燊（河南）医药科学技术有限公司
地址：河南自贸试验区郑州片区（经开）航海路经开第二大街航海东路1291号
邮箱：haifeng.zhang@pannacean.com
电话号码：0371-55159968
QQ :3651580365 1816685755
攀纳燊（河南）医药科学技术有限公司
地址：河南自贸试验区郑州片区（经开）航海路经开第二大街航海东路1291号
邮箱：haifeng.zhang@pannacean.com
电话号码:0371-55159968