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6-Azauridine

目录号:

所属分类:

核苷衍生物

应用与生物特性:

Antimetabolic antineoplastic drug抗代谢抗肿瘤药; Anti-bacterial, antitumor, and antiviral agent; Substrate of uridine kinase; Competitive inhibitor of orotidine 5’-phosphate decarboxylase; Toxicity: LD50 oral: > 316 mg/kg
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产品详情


Catalog No. P1001
Name 6-Azauridine
Synonyms Azauridine; 6-Azauracil riboside; 1-(beta-D-Ribofuranosyl)-6-azauracil
中文名称 6-氮杂尿苷,氮杂尿苷
Formula C8H11N3O6
FW 245.19
CAS No. 54-25-1
HPLC ≥ 97%
Package Packed as desired
Classification 原料药; 核苷衍生物
Property Appearance and Property: white solid powder; Hygroscopic
m. p.: 160-161 °C (lit.)
Density: 1.4866 g/cm3 (estimated)
Solubility: soluble in water, slightly soluble in DMSO, methanol, ethanol, pyridine
Storage: sealed at 2-8 °C or room temperature
Acidity (pKa): 6.70 (at 25 ℃)
Application & Biological Property Antimetabolic antineoplastic drug抗代谢抗肿瘤药; 
Anti-bacterial, antitumor, and antiviral agent; Substrate of uridine kinase; Competitive inhibitor of orotidine 5’-phosphate decarboxylase
Toxicity: LD50 oral: > 316 mg/kg
References
  1. Wang, M. C.; Bloch, A. Biochem. Pharmacol. 1972, 21, 1063.
  2. McPartland, R. P.; Wang, M. C.; Bloch, A.; Weinfeld, H. Cancer Res. 1974, 34, 3107.
  3. Brockman, R. W.; Shaddix, S. C.; Williams, M.; Nelson, J. A.; Rose, L. M.; Schabel, F. M., Jr. Ann. N.Y. Acad. Sci. 1975, 255, 501.
  4. Robins, M. J.; Currie, B. L.; Robins, R. K.; Bloch, A. Proc. Am. Assoc. Cancer Res. 1969, 10, 73.
  5. Khare, G. P.; Sidwell, R. W.; Huffman, J. H.; Tolman, R. L.; Robins, R. K. Proc. Soc. Exp. Biol. Med. 1972, 140, 880.
  6. Shannon, W. M.; Brockman, R. W.; Westbrook, L.; Shaddix, S.; Schabel, F. M.; Jr. J. Natl. Cancer Inst. 1974, 52, 199.
  7. Shannon, W. M.; Arnett, G.; Schabel, F. M., Jr. Antimicrob. Agents Chemother. 1972, 2, 159.
  8. Handschumacher, R. E. J. Biol. Chem. 1960, 235, 764.

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